What is ozone therapy

Ozone Therapy is a medical therapy whereby ozone is introduced into the human body. Ozone is O3, whereas the oxygen we breathe is O2. Ozone has been used successfully around the world as integrative method for over 80 years to treat:

  - Pain
  - Infections
  - AIDS
  - Diabetes
  - Stroke
  - Depression
  - Chronic Fatigue
  - Lupus
  - Fibromyalgia

and over 150 more diseases. In some clinics around the world, ozone is the first agent given to each and every patient that enters the clinic regardless of their ailments. Ozone addresses the key issues in almost all disease conditions: oxygen delivery, circulation, and immune system function.
Ozone Therapy has proven beneficial effects such as:

  - increasing oxygen delivery to cells, tissues, and organs
  - increasing blood circulation throughout the body
  - detoxification
  - boosting of the immune system


With regards to the debate of the merits of ozone therapy, the promotional claims by some marketers of ozone generators that it is a miraculous cure for all disease including cancer and AIDS have given many people false hope and hurt the credibility of ozone therapy. Leading the opposing argument is the US Food and Drug Administration who state that ozone is a toxic gas with no known useful medical application in specific, adjunctive, or preventive therapy and in order for ozone to be effective as a germicide, it must be present in a concentration far greater than that which can be safely tolerated by man and animals. The FDA recently approved ozone’s use as a disinfectant in the food processing industry, however.
Perhaps we do not agree fully with any of the previous theories. Sure, Ozone could not be intended as the panacea of any medical problem like manufacturers says, but we can’t agree with the opponents at the lights of the numerous literatures on ozone as therapeutic potential. We can’t forget also that a strong conflict of interest make not believable the arguments of the critical of the ozone uses!

Neither the Journal of the American Medical Association (JAMA) nor the Geneva-based World Health Organization (WHO) have published any research reporting benefits of ozone use in medicine. However in international peer reviewed medical journals hundreds of articles have been published reporting positive outcomes of medical ozone research and application for a range of pathology. Most of these were published since 1990 and are accessible on Medline, and they include pre-clinical studies, animal experiments, patient case histories, placebo-controlled blinded human trials and reviews. The authors are mostly from Italy, Poland, Russia, Germany, Cuba, Spain, Israel, Japan and United States of America, and they draw conclusions that conflict with the FDA. The literature in their native languages is more abundant.
Gérard V. Sunnen has made claims that medical use of ozonating blood to kill viruses and bacteria in the blood shows a potential area for scientific research.


Ozone therapy is a well established integrative and complementary therapy in most mainland European countries where health authorities have tolerated its practice. The European Cooperation of Medical Ozone Societies, founded in 1972, publishes guidelines on medical indications and contraindications of ozone and hosts training seminars. In the early 1980’s, a German survey and investigation into ozone therapy by the University Klinikum in Giessen and the Institute for Medical Statistics, published in the Empirical Medical Acts revealed over 5 million ozone treatments had been delivered to some 350,000 patients, by more than 1000 therapists, of this number about half were medical doctors. Although ozone is used in a complementary capacity by a significant number of doctors in Italy, Switzerland, Austria and Germany, it has still not gained popular support with mainstream industry policy makers in those countries, it is not covered by health insurance, nor is it part of the curriculum at most esteemed medical schools. Proposals to include ozone therapy in German health insurance schemes invoked hostile objections from pharmaceutical researchers who question its evidence base. In general, countries with more socialist-style health systems seem to have had less difficulty in accepting ozone as a medicine. No prohibition of ozone therapy is evident in Bulgaria, Cuba, Czech Republic, France, Germany, Greece, Israel, Italy, Japan, Malaysia, Mexico, Poland, Romania, Russia, Switzerland, Turkey, United Arab Emirates and Ukraine. In the USA, recently passed Alternative Therapy Legislation has made ozone therapy an option for patients in some states. In Alaska, Arizona, Colorado, Georgia, Minnesota, New York, New Jersey, North Carolina, Ohio, Oklahoma, Oregon, South Carolina, and Washington, physicians can legally use ozone treatments in their practice without fear of prosecution.


Studies by Dr. Paul Wentworth Jr. and colleagues at the Scripps Research Institute USA have led them to believe ozone is naturally created by human neutrophils (a type of white blood cell) in the context of immune system function. The same researchers have also discovered evidence that ozone may be produced in atherosclerotic arteries as a by-product of inflammation. Others have argued that the Scripps studies are inconclusive, since the biomarkers used to determine the production and reaction of ozone could also be evident with non ozone dependent reactions. So to date it is uncertain whether ozone has a natural physiological role. If ozone is indeed produced endogenously by the human immune system, even skeptics have conceded this would be of great significance and give merit to the concept of ozone as a medicine. A number of other gas molecules have been confirmed as having essential biological functions including cell signaling.


1- Inactivation of bacteria, viruses, fungi, yeast and protozoa: ozone disrupts the integrity or the bacterial cell envelope through oxidation of the phospholipids and lipoproteins.

2- Enhancement of circulation: In circulatory disease, the clumping of red blood cells hinders blood flow through the small capillaries and decreases oxygen absorption due to reduced surface area. Ozone reduces or eliminates clumping and red cell flexibility is restored, along with oxygen carrying ability. Ozone also oxidizes the plaque in arteries, allowing the removal of the breakdown products, unclogging the blood vessels.

3- Modulation of the immune system: Administration of ozone causes an increase in the production of interferon, interleukin TNF (tumor necrosis factor), and interleukin.